Prevalence of Intrauterine Fetal Death in Iran: A Meta-Analysis and Systematic Review
2 Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran, Email: [email protected]
3 Department of Obstetrics and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Royan Institute, Reproductive Biomedicine Research Center, ACECR, Tehran, Iran
Citation: Keikhaie KR, et al. Prevalence of Intrauterine Fetal Death in Iran: A Meta-Analysis and Systematic Review. Ann Med Health Sci Res. 2018;8:275-278
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Introduction: Intra uterine fetal death (IUFD), means the intrauterine death of the fetus before birth after 20 weeks of gestation, with a fetus weighing more than 500 g. The main causes can be classified into three groups of maternal, fetal, and placenta causes. Aim: The aim of the present systematic review and meta-analysis was to assess the prevalence of intrauterine fetal death in Iran. Methods: The prevalence of intrauterine fetal death was defined based on the international criteria and the measured outcome of the disease. Study selection, data extraction, and quality assessment were performed by two independent reviewers. Qualified studies were searched in Medline (PubMed), web of science, and Embase. All peer reviewed articles published by the end of 2017 were included during the process of searching. Cochran test and I2 index were used to evaluate heterogeneity of studies. Collected data was analyzed using Stata 12.0. Results: Of 263 studies, 5 studies utilized meta-analysis In 2017, the pooled overall prevalence of intrauterine fetal death in 44161 people was 4.9% (95% confidence interval [CI]:2.50, 4.60, I2 = 98.60%). Conclusion: Regarding the high prevalence of intrauterine fetal death in Iran two basic cases, including the birth registration of all babies and the provision of appropriate pregnancy care are essential in order to prevent stillbirth. To reduce the incidence of stillbirths, it is necessary to record the prevalence, untimely deaths, and the ways in which risk factors lead to stillbirths with higher precision and accuracy; finally, it is necessary to evaluate strategies the implementation of which might decrease the rate of stillbirth.
IUFD; Iran; Systematic review; Meta-analysis
Intra uterine fetal death (IUFD) means the intrauterine death of the fetus before birth after 20 weeks of gestation, with a fetus weighing more than 500 g. The main causes can be classified into three groups of maternal, fetal, and placenta causes. [1,2] Although intrauterine death has been significantly reduced in the last 30 years but, studies conducted on the prevalence of this phenomenon in developing countries show that, intrauterine death has not experienced significant decrease in these countries; the cause of about two thirds of fetal deaths is still unknown.  However, main reasons can be divided into three categories of maternal, fetal, and placental. The results of Hemtyar et al. study showed that congenital anomalies were the most common cause of fetal death, the separation of placenta was the most common placental cause and maternal diabetes mellitus was the most common cause of maternal death;  maternal factors involved in intrauterine death of the fetus include gestational hypertension, insulin-dependent diabetes, high obesity, lack of activity, illiteracy, infectious diseases of mother and familial marriage, history of complicated labor, social and economic conditions, maternal and fetal injuries, anti-phospholipid antibodies, diabetes, hypertensive disorders, trauma, liver disease, sepsis, acidosis, Hypoxia,, and post-term pregnancy.  Embryonic causes include congenital malformations (anencephaly and neural tube defects), mecuniom passage in utero, and intrauterine growth retardation.  Although it is difficult to prevent stillbirth, the incidence of intrauterine deaths can be decreased with perinatal care and consultation, early diagnosis and accurate measurements. Intrauterine fetal mortality and morbidity is a very sensitive indicator of the health status of the community; it can also obscure future pregnancies and, in addition to imposing a huge cost, the family, especially the mother, will suffer severe consequences.
The present study was conducted in several stages including accurate determination of the problem under study, collection, analysis and interpretation of the findings; additionally, preferred systematic reviews and meta-analysis (PRISMA) guidance system was used. Therefore, all stages of the research, such as search, selection of studies, qualitative evaluation, and data extraction were carried out independently by two researchers. In case of disagreement, the point was shared in group discussion and settled using the third researcher’s view.
Qualified studies were searched in Medline (PubMed), web of science, and embase. All peer reviewed articles published by the end of 2017 were included during the process of searching. An electronic search strategy was implemented in collaboration with a librarian who had extensive experience in systematic review. The search was conducted in the Internet using Persian and English keywords including intrauterine death, pregnancy complications, Iran, mortality, perinatal, IUFD Mortality study, Prenatal and Maternal Disease; additionally, AND and OR coordinators were used to provide more extensive search. For further studies, the reference was made to all articles related to the topic.
Inclusion and exclusion criteria
Qualified papers included collaborative studies, cross-sectional studies, case control studies, common health care studies in Iran that were published by the end of 2017; reviewed articles, discussion articles, non-research letters, case studies, and case series plus animal studies and all randomized controlled trials were excluded from the study.
Selection of relevant studies
The titles of the retrieved articles were reviewed by two independent researchers and qualified papers were selected based on intended criteria and categorized into three groups of included, non-included and unsure. The abstract of papers categorized in the unsure group were restored and re-categorized after further discussion. Full copies of relevant studies were obtained, and their competence for independent inclusion was evaluated by two researchers. Any contradiction was solved by consensus or judgment of a third researcher.
Risk of bias in evaluation
The risk of bias in studies was independently assesses by two researchers using relevant versions of the Critical Appraisal Skills Program (CASP) tool (http://www.casp-uk.net/). The articles were ranked based on various components of the study (the appropriateness of the design of the study for the research question, the risk of choice bias, exposure, and evaluation of the result). The differences were solved by consensus or the view of the third researcher.
The present research investigated 5selected papers that were eligible to enter the secondary analysis process. Descriptive details of the articles are presented in Table 1; [7-20] a form comprised of three parts was designed in this section. Then, the basic data required for analysis, including bibliographic data, title, the name of the journal and author, methodology information including the method of study and type of plan, as well as information on the prevalence of hospital infections and their risk factors and general characteristics of the samples, target group or groups, and quantitative data, such as the mean age of patients, were collected [Table 1].
|Authors||Publication year||City or town of study||Prevalence||Sample size||Type of study|
|Zarei et al. ||2009||Ahvaz||4.1||953||Retrospective case-control|
|Nan Bakhsh et al. ||2006||Urmia||3.34||6877||Descriptive cross-sectional|
|Zand Vakili et al. ||2016||Zahedan||1.61||270||Cross-sectional|
|Safarzadeh et al. ||2014||Sanandaj||8.87||9090||Case control|
|Vakilian et al. ||2016||Arak||1.98||26971||Cross-sectional|
Table 1: Characteristics and information of papers related to IUFD.
The variance of each study was calculated according to binomial distribution. Studies were combined with sample number and variance. Due to the heterogeneity of the studies, a random effects model was used to combine the studies. Cochran test and I2 index were used to evaluate heterogeneity of studies. Collected data was analyzed using Stata 12.0.
In this retrospective-controlled study, we recruited 172 patients admitted to the Educational Hospital affiliated to our university, who had undergone empyema treatment in two groups from 2001 to 2009. The ethical approval for this study was obtained from the Ethics Committee of the university (the names of ethics committee, hospital, and university have been removed because of journal’s anonymous policy for authors and will be added upon acceptance and proof galley procedure).
In a systematic review of articles by two researchers, 226 articles were found; after reviewing the titles, 34 repetitive articles were deleted. After reviewing the full text of 192 articles, 187 papers were deleted [Figure 1]. Finally, 5 studies, completed by the end of 2017, entered the final process [Figure 1]. The total sample size was 44,161. Table 2 shows the general profile and data for each of the examples mentioned.
|Study/Year||ES||95% CI for ES||% Weight|
|Nan Bakhsh (2004)||0.033||0.029||0.038||56.27|
|Zand Vakili (2016)||0.016||0.001||0.031||4.30|
|Overall random pooled ES||0.049||0.046||0.052||100.00|
Table 2: Subgroup analysis done for diagnosis of heterogeneity base on study participants.
According to the random effects model, the incidence of intrauterine fetal death in Iran was estimated to be 4.9% (95% confidence interval from 4.6 to 5.2). The studies are presented in Table 2 according to the year and the city in which they were conducted. Given the heterogeneity of studies, the confidence interval for each study and for individual studies based on the random effects model is presented in Figure 2.
Figure 2: The incidence of intrauterine fetal death and its 95% confidence interval for the studied cases according to the year and the city where the study was conducted based on the model of the random effects model. The midpoint of each section of the line estimates the% value and the length of the lines showing the 95% confidence interval in each study. The oval sign shows the incidence of intrauterine fetal death for all studies.
Stillbirth, the worldwide rate of which has been reported to be 2.6 million cases, 97% of which occur in developing countries, each year, is one of the most common adverse effects of pregnancy. [7,8] This phenomenon has decreased quite significantly in many countries, especially in developed ones, over the last decades;  a huge part of this decline has occurred in near-term term deliveries, mainly due to improvement of medical care. [10,11] Despite such changes, stillbirth currently accounts for about half of all perinatal deaths and more than one-third of all deaths from 20 weeks of age up to 1 year. However, data on stillbirth rate rarely turns out to be accurate, because reports that are lower than existing ones are a major problem in many geographic areas. Increasing the frequency of reports in recent years has made it difficult to understand the process of stillbirth, especially in the early gestational age.  The prevalence of this disorder and its risk factors in different regions can help provide timely diagnosis, appropriate treatment and prevention of complications. According to the results of the present study, which was conducted to determine the prevalence of stillbirths reported in 5 studies examining 44161 patients among Iranian pregnant women by the end of 2017 the rate of stillbirth turned out to be 4.9%. In a systematic review of the incidence of stillbirths in America, Asia, Europe and Africa in 2009, 63 countries outnumbered the incidence of stillbirths, according to 63 studies from different countries, the rate of which varied from 0.40% in Western Europe to 3.19% in West Africa.  According to the results of present study, the prevalence of stillbirths varies from 1.61 to 8.87 according to a review of 5 studies from various Iranian cities in 2013-2017. The highest prevalence turned out to be in Zahedan and the lowest incidence was Sanandaj. In a study conducted in central India in 2017, the incidence of intrauterine death was reported to be 5.62%, the majority of which was primigravida and the most common cause was hypertention (41%). As for the present study, the prevalence of emergency visits due to IUFD was reported to be 66%, while pre-arranged admissions due to IUFD cases were 33.9%.  Also, in another study conducted in 2016 in Bangladesh, the prevalence of intrauterine death was 2.6%. According to the results of present study, the incidence of intrauterine death was higher in primigravida women (44.6%), and 28.7% of cases had hypertension; additionally, there was no specific cause for 19.5% of intrauterine deaths.  The results of a study conducted in Saudi Arabia in 2006, indicated 28% of intrauterine deaths occurred without any specific cause. 
Firstly, the data is mainly available for hospital births, while there is a large proportion of births at home; secondly, limited studies are conducted based on community in Iran, especially in remote areas, where information on mortality rate might not be available.
To put it in a nutshell, stillbirth is one of the most common adverse consequences of pregnancy in developing countries; however, the number of studies is limited. According to the present study, two basic cases, including the birth registration of all babies and the provision of appropriate pregnancy care are essential in order to prevent stillbirth. To reduce the incidence of stillbirths, it is necessary to record the prevalence, untimely deaths, and the ways in which risk factors lead to stillbirths with higher precision and accuracy; finally, it is necessary to evaluate strategies the implementation of which might decrease the rate of stillbirth.
Conflict of Interest
The authors disclose that they have no conflicts of interest.
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