Innocent E Francis1, Khalid Seedahmed1, Nonhlanhla Khumalo2 and Ian Louis Ross1*
 
1 Division of Endocrinology, Department of Medicine, University of Cape Town, South Africa
2 Division of Dermatology, Department of Medicine, University of Cape Town, South Africa
 
*Correspondence: Ian Louis Ross, Division of Endocrinology, Department of Medicine, University of Cape Town, 47 Old Main Bldg, Groote Schuur hospital Observatory Cape Town 7925, South Africa, Tel: +27214045007, Fax: +27214066513, Email: [email protected]

Citation: Francis IE, et al. Topical Steroids Inducing Cushings Syndrome and Subsequent Adrenal Axis Suppression. Ann Med Health Sci Res. 2019;9: 629- 632

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Abstract

We present the case of 19-year-old migrant woman presented to our teaching hospital with features of Cushing’s syndrome. While she gave no history of oral steroid use, she had used creams from an informal market to improve her appearance. She used these creams for several years, but had stopped these a month prior to presentation. She was amenorrhoeic and had difficulty falling pregnant for several years and biochemistry confirmed that she had inadequate cortisol reserve, indicative of hypothalamic pituitary adrenal axis suppression. We examine the risk factors for development of Cushing’s syndrome along with describing the available literature on hypothalamic-pituitary adrenal axis suppression in this setting. Despite the controls and legislature, illegal sale of these creams, with origins in Europe, India and USA is ongoing. We call upon improved law enforcement to prevent export and illegal sales to vulnerable persons.

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