Case Reports
Successful Management of BK Virus Nephropathy
Following Kidney Transplant in Nigeria: A Report of
Two Cases
Author(s):
Olatise O Olalekan, Olatise O Olalekan*, Adekoya Adebowale, Adekoya Adebowale, Obajolowo Omotola, Muoka Michael, Faponle Ade Faponlegboyega and Ameh I Oluwatoyin
BK Polyomavirus Associated Nephropathy (BKVAN) is an important emerging complication of renal transplantation. BK Virus (BKV) is an opportunistic pathogen that actively replicates in those with impaired immunity and its emergence is attributed to the use of more potent immunosuppressive drugs following renal transplant. The virus induces cytopathic changes in renal cells with commonly asymptomatic presentation, but if left untreated, leads to nephropathy and graft loss. Management of this emerging complication in transplant centres in Nigeria has not been reported. We therefore describe the successful treatment of BKVAN in two patients who had progressive impairment of renal function post-transplantation. A reduction in the dose of tacrolimus and withdrawal of Mycophenolate Mofetil (MMF) in the case 1 and replacement of MMF with Sirolimus in addition to a .. Read More»
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.