Introduction: Polycystic kidney diseases are common disorders and are considered as common causes of end stage renal disease, both in children and in adults. General surgeons, neonatologists, pediatric urologists, nephrologists and general physicians frequently encounter patients with polycystic kidney diseases. The article describes the main embryological reasons behind cyst formation in polycystic disease not restricted to kidneys only but to other organs as well.
Method: The study was compiled in SKIMS Soura and SKIMS Bemina with review of literature from all standard text, latest references from standard indexed journals along with determining the basic embryological basis of this disease.
Conclusion: It is prudent for a physician, surgeon, nephrologist or urologist to completely understand the embryological basis the defects in cilia, polycystins and cellular signaling behind the polycystic kidney disease reducing progression to kidney failure requiring dialysis and transplantation.
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