Aplastic Anemia and Therapeutic Options

Author(s): Samuel Kofi Arhin

Aplastic anemia refers to a failure of the bone marrow. The majorcharacteristic of Aplastic Anemia (AA) is marrow hypoplasia and theexhaustion of hematopoietic precursors which then result in pancytopenia.Patients with AA exhibit symptoms that are related to a reduction in bonemarrow production of hematopoietic cells. Signs and symptoms associatedwith Aplastic anemia include swelling of feet, gingival bleeding, petechialrashes. Palpitations, pallor, frequent headaches, dyspnea, and oropharyngealulcers. The disease is fatal and thus requires immediate interventionsmeasures. The deficit in hematopoietic cellular often leads to hemorrhageand severe anemia. The most suitable and recommended method oftreatment for patients suffering from AA is allogeneic bone marrowtransplantation from a matched HLA sibling.


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