Background: There are some debates about the association between metabolic syndrome and androgenic alopecia. Regarding the controversies, this study was conducted to determine the association between metabolic syndrome and androgenic alopecia. Materials and methods: In this case-control study, the case group included those subjects with androgenic alopecia attending to dermatology clinic of two training hospitals (n=57) and the control group was selected subjects attending to these hospitals without androgenic alopecia (n=54). The blood sample was obtained and assessed for FBS, TG, LDL, TC, and HDL levels. The weight and height (for body mass index), waist circumference, and blood pressure were assessed in both groups and were recorded in checklist. Finally the frequency rate of metabolic syndrome was compared between two groups. The ethics committee approval code for present study is IR.IUMS.REC 1392.8521215625. Results: In case and control group, there were 37 (64.9%) and 29 (53.7%) cases with metabolic syndrome, respectively showing statistically significant difference (P < 0.0001). The frequency rate of abnormal blood sugar, serum triglyceride, and total and HDL cholesterol was higher in case group (P < 0.05). Conclusion: According to the obtained results it may be concluded that there is significant association between metabolic syndrome and androgenic alopecia.