Dyslipidemia & local inflammation are the two major determinants of cardiovascular disease (CVD). Atherosclerosis leads to inflammation which is triggered by dyslipidemia. In this study we have tried to find out a correlation between lipid profile parameters & hsCRP, which is a very sensitive marker for inflammation. In this study hsCRP and the Lipid profile parameters were estimated in fifty two patients who visited the medicine OPD of College of Medicine & JNM Hospital, Kalyani. The results obtained indicate a strong significant positive correlation of total cholesterol (p value <0.001) and triglycerides (p value=0.032) with hsCRP and a negative correlation of HDL (p value=0.36) with the same. These results indicate that there may be a role for hsCRP in screening and risk stratification of atherosclerosis.