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Catheter-Based Renal Denervation in Patients with Uncontrolled Hypertension in the Absence of Antihypertensive Medications (SPYRAL HTN-OFF MED): A Randomised, Sham-Controlled, Proof-of-Concept Trial

Author(s): Fahad Khan*, Syeda Nimrah Ali and Fizza Tariq

Increasing burden of hypertension worldwide has stirred a lot of research work regarding the establishment of its effective treatment. The clinical trial ‘Catheter based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomized, sham-controlled, proof-of-concept trial’ published in ‘The Lancet’ (2017; 7: 0140-673) has explored a procedure called ‘Renal Denervation’ as a possible treatment for resistant hypertension. We read this article with great interest and congratulate the researchers for confirming the efficacy of renal denervation in patients with mild to moderate hypertension.


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