Background and Aim: Investigating one-visit treatment regimens which would have the same biological effectiveness of a two-visit procedure is of considerable importance. The purpose of this systematized review was the Clinical and radiographic one-and twovisit endodontic treatment evaluation with apical periodontitis. Method: The Controlled Trials of Cochrane’s (CENTRAL) Register was explored by applying the Endodontics, One, Two, Single, Multiple, Appointment, Visit Terms, with no language restriction. 196 studies were conducted using the primary analysis in total. 5 articles among the 196 studies were chosen to have more precise criteria. Review methods: Randomized controlled trials and controlled clinical trials of root canal treatment of Single-versus multiple-visit carried out in humans were identified. The obtained result was the healing of radiographically detectable lesions in where data extraction was independent. Result: The mean number of human teeth was 112.60, and the lowest 44 patients and the most 300 patients, the standard deviation was 106.45. The mean of human teeth in the single visit groups was 58.6 (54.94) and in the two visit groups 54 (51.53). Risk differences of included studies were combined. Conclusion: root canal treatment of two and singlevisit represented approximately similar success in the periapical pathology endodontic treatment of teeth.