Correlation of Serum Ferritin Level with Severity of COVID-19 Infection: A Retrospective Cross Sectional Study in a Tertiary Care Centre, Aurangabad, India

Author(s): Vijaykumar S Gulwe, Potu Sanjana Reddy, Sanjay Govindrao Guddetwar, Malempati Bharadwaja and Abhilash R Taware

Background: COVID-19 has been declared a global public health emergency by the World Health Organization. Serum ferritin levels are closely linked to the covid-19 disease in previous studies. Aim: Iron metabolism undergoing significant modifications in covid-19 disease hence Serum ferritin levels can be employed in predicting severity. Materials & Methods: 30 SARS-CoV-2 positive patients diagnosed on Reverse-Transcriptase Polymerase Chain Reaction (RTPCR) test were enrolled. They are divided into severe and non-severe groups. Serum ferritin was measured by Chemi Luminescence Immune Assay (CLIA) in all 30 patients. Result: In group I on day 1 it was 308.2 ± 12.51 and on day 7 it was 311.09 ± 11.52. In group II on day 1 it was 312.9 ± 11.10 and on day 7 it was 770 ± 36.25. Statistically significant result found on day 7 between group I and II (P<0.0001) whereas no significant difference found on day 1 (P=0.2857). Conclusion: Inflammatory cytokine storm is associated with severity of COVID 19. Ferritin despite representing total body iron stores is linked with acute and chronic inflammatory processes. Serum ferritin can be considered in combination with clinical details and other laboratory tests in designing the patient centered treatment plans.


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