Corticosteroid Intervention in Management of Coronavirus COVID 19 Infection A Systematic Review and Meta Analysis

Author(s): Abdulrahman Abdullah AIbakr*, Navin Anand Ingle, Mansour K Assery and Mohammad Abdul Baseer

Introduction & Aim: The coronavirus disease is very intense and widely spreading across the world. Different treatment modalities are unsuccessful till date. Many researchers are still finding out the drug to cure COVID – 19 diseases. This review is to assess corticosteroid intervention in COVID-19 patients for outcomes of mortality and morbidity. Methods: Literature search of published articles in Medline, Scopus, Ovid and Journal of Web till June 2020 were reviewed for the pre-described outcomes. RevMan 5.4 software was used for analysis of study. Results: Of the 186 articles chosen, 6 were chosen for qualitative analysis and 3 for quantitative analysis. Meta analytic comparison showed that mortality rate was higher in patients treated with corticosteroids (OR = 0.98, 95% CI = 0.72 – 1.34, p<0.0001) than those without. 337 patients died out of 1389 corticosteroid managed COVID -19 patients. Conclusion: Corticosteroid usage increases the odds of increased mortality among COVID -19 patients.


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