Background: Depression is a common and typical disorder, described bysadness, loss of interest or pleasure, feeling of guilt, disturbed sleep orappetite, feeling of tiredness and poor concentration. The most vulnerabletime for depression in women is considered to be during pregnancy whichranges from 4-20%.Objectives: Objectives of this study was to analyze the descriptiveepidemiology of antenatal depression and to assess the risk factor ofantenatal depression among women.Methods: A hospital based cross sectional survey was conducted in LadyAitchison Hospital. Data was collected by using convenience samplingtechnique. The survey was conducted during the month of December 2016 toMarch 2017. Information regarding risk factors of prenatal depression inlocal language or using structured questionnaire and categorized fordepression as following by using Edinburgh Postnatal Depression Scale(EPDS). Data was analyzed by using SPSS version 20 and applied chi squaretest to find out association between risk factors and depression.