Trismus is a disease that is associated by muscle spasms in the jaw muscles, pain, and inability to open the mouth. Trismus is a Sympathomimetic effect of chronic use of methamphetamine. This study was carried out aimed to evaluate the efficacy of ear acupuncture on the pain and mouth opening in chronic methamphetamine-dependent patient. We report a case of 31-yearold young man with Trismus syndrome consequence of chronic use of methamphetamine with severe mouth pain. We applied ear acupuncture for three weeks to ameliorate pain and hopefully improve his functional ability to Mouth opening. Results were analyzed by generalized estimating equations (GEE) models. The primary outcome showed that Ear Acupuncture has not a significant effect on reducing the frequency of urine test during treatment. Also secondary outcome showed that there was not a significant reduction in pain index and mouth opening. According to the failure in the production of tyrosine Hydroxylase as a precursor to produce dopamine in chronic methamphetamine users and the role of dopaminergic system in the modulation of orals facial pain, the effectiveness of acupuncture could be in jeopardy.
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