Purpose: This study performed an effect-size analysis of instrument assisted soft tissue mobilization for increase range of motion. Subjects & Methods: The database search was conducted using pubMed, web of science core and google scholar. The metaanalysis was based on 20 studies, covering a total of 638 participants, and used a fixed effects model. Results: The effect size estimate show that instrument assisted soft tissue mobilization had a significant effect on increase range of motion (SMD: 4.72, 95% CI: 3.98-5.45). Conclusion: The finding from this review suggest that instrument assisted soft tissue mobilization is effective at improve range of motion. However, further research is needed, large sample size, to provide evidence-based recommendations.