Efficacy of Gymnema Sylvestre as a Potent Antioxidant: An In Vitro Study

Author(s): Keerthika R and Sandhya Raghu*

Background:Antioxidants are the substances which act as radical scavengers and help in conversion of reactive oxygen species, thus preventing the cellular damage. In recent times the synthetic antioxidants are substituted by natural antioxidant, which are primarily derived from plant sources. It has been proven that these antioxidant properties of the medicinal plants are mainly due to its phytochemical constituents. Gymnema sylvestre is one such traditional ayurvedic herb used primarily for the treatment of diabetes and other ailments such as arthritis, anemia, diuretics, etc.
Aim: The aim of this study is to analyse the antioxidant potential of ethanolic extract of Gymnema sylvestre in comparison with the ascorbic acid.
Materials & Methods: The ethanolic extract of Gymnema sylvestre was prepared and the antioxidant potential of the extract at different concentrations (25,50,100,200 μg/ml) was tested using DPPH assay and ABTS radical scavenging activity and reducing power assays are designated by their IC50 (concentration required to attain 50% radical-scavenging effect) and compared with that of the standards (Ascorbic acid).
Results: It is shown that there is concentration dependent antioxidant activity of ethanolic extract of Gymnema sylvestre with IC50 of Gymnema sylvestre found to be 74.8 μg/ml and 83.8 μg/ml by ABTS and DPPH assay respectively.
Conclusion: Within the limitations of this study it can be concluded that ethanolic extract of Gymnema sylvestre has considerable dose dependent antioxidant property when compared with ascorbic acid. However, further preclinical and ex vivo studies have to becarried to prove its use in clinical trials.


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