With the growing development of nanotechnology and the increase in exposure to nanoparticles, there is an urgent need for more studies to assess the toxicity caused by these particles to the body and to find ways to avoid their harmful effects. This experiment was designed to estimate the toxicity of Zinc Oxide Nanoparticles (ZnONPs) on rats hepatic function parameters, and then noting the beneficial effect of Cichorium Intybus (CI) on those disorders that may be caused by ZnO-NPs. 24 male rats were randomly divided into 4 groups, each group comprising 6. CON group without treatment, the ZnO-NPs group received ZnO-NPs, in the ZnO-NPs+CI group animals were co-administered with a combination of ZnO-NPs with CI, and finally the animals of the CI group were dosed only with CI extract. Levels of hepatic biochemical parameters including ALT, AST and ALP were measured to detect toxic changes in the liver. The study found that ZnO-NPs caused a significant increase in the activity of those serological parameters compared to the control. But it was seen that the combined treatment of CI led to a clearly reduce in the levels of hepatic parameters in the serum. Thus, we can consider Cichorium Intybus as a medicinal plant capable of reducing the ZnO-NPs hepatotoxicity in laboratory rats.
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