Objective: The purpose of this study was to see the amalgamation between the hemoglobin levels and MCV levels with dental caries in a random sample of pediatric patients who visited the Abha Maternity Hospital, Abha. Design: Cross-sectional study. Setting: Hospital based. Subjects: Total 122 children aged 3-12 years. Intervention: Dental caries using dmft index and laboratory data of hb and mcv were obtained from patients medical records. Main outcome measure: Evaluation and amalgamation of hemoglobin and mcv levels in children with dental caries. Results: In this crosssectional study there was no significant difference in mean age (6.3 ± 2.7 years) mean dmft was 3.79 (S.D=4.2) and mean Hb was 11.69 (S.D.=1.8). Pearson’s correlation coefficient showed there was a strong inverse correlation between Hb levels and dental caries; but no association was found with MCV levels and dental caries. Conclusion: This study concluded that children with high caries experience were found to be suffering from low Hb levels. The need for further longitudinal studies needs to be conducted to the association between the two conditions.