Malnutrition affects more than 95.9% of population in developing nations, and it has a big impact on children's health and their development and also associated with high morbidity impact and it is linked with changes in immunological-cytokines. The researchers needed to look at pro-inflammatory mediators in both healthy and underweight children. The goal of present study was to find and compare the levels of pro-inflammatory cytokines in the control (healthy) and malnourished children. A total of 151 children were involved in this study, including 96 malnourished children and 55 healthy children of identical age and gender. The clinical, demographic, and plasma levels of Interleukin-1beta (IL-1beta) and 6, Tumor Necrosis Factor-alpha (TNF-alpha) and C-Reactive Protein (CRP) of these subjects were all evaluated using an ELISA kit. When compared to healthy children, malnourished children experienced a considerable reduction in weight and Weight-for-Age Z score (WAZ). Furthermore, the levels of serum interleukin-1 (IL-1) (0.10 vs 0.05) and serum Interleukin-6 (IL-6) (pg/ml), (1.5 vs 1.6), TNF-alpha (pg/ml) (1.7 Vs 1.8), and CRP (mg/l) (0.7 Vs 1.0) were significantly higher in the malnourished group compared to the control group. Pro-inflammatory cytokines (IL-1, Interleukin-6 (IL-6), TNFalpha and CRP were found at higher concentrations in the blood of malnourished children.