Aim: Melanoma is the most aggressive and dangerous of the skin cancers and its incidence has been increasing for several decades. This pathology is therefore has become a major health issue for Western populations. Yet if the primary melanoma is generally of good prognosis, once the metastatic stage reached, no effective therapeutic solution is currently available. Targeted therapies promising are still being developed such as BRAF inhibitors. Case Report: We present a case of metastatic nodular melanoma. A 43-year-old woman was admitted to our hospital exophthalmia with brain, pulmonary and adrenal metastasis. Conclusion: The incidence of melanoma continues to rapidly increase in the world. Detecting molecular markers aids diagnosis and identification of mutations BRAF, not only helps to diagnosis and prognostic, but also to guide treatmentand radiotherapy can potentiate the response by immuno stimulatory property.