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Exploring Toxicological and Safety Status Evaluation of an Ayurveda Medicine used for Indigestion in South Asian Region


Asma Kabir*, Md Ibrahim, Mohammad Nurul Amin, Farhana Sultana, Munny Das, Dipti Debnath and Tonmoy Debnath

Aim: Brhad Agnikumara Rasa (BAR), an Ayurvedic preparation used as a traditional medicine in the treatment of indigestion in the Asian population. Sample: For this present study, Brhad Agnikumara Rasa (BAR) had been collected from Sri Kundeswari Aushadhalaya Ltd., Chittagong. Study design: Healthy albino rats were used for the toxicological evaluation of BAR. During this experiment, rats were randomly divided into two groups of five rats/group and a dose equlibrium to 400 mg/kg body weight was selected for this toxicological evaluation. Place and duration of Study: This study was carried out between June 2015 and July 2016 at Pharmacy department of Atish Dipankar University of Science and Technology. Methodology: To established safety status of BAR, healthy albino rats (Sprague-Dawley strain) (50-70 g) were used. Rats were randomly divided into two groups of 5 rats/group. BAR was administered chronically to the experimental rats at a dose equlibrium to 400 mg/kg body weight for 51 days. To assess the function of the liver and kidney various biochemical analysis were carried out by using rats serum. Results: Our findings showed that total protein content was increased (7.493%) in the BAR treated rats. The increase in total protein though not found statitically significant (p=0.088). Interestingly, the serum albumin content was statistically insignificantly (p=0.141) increased (14.657%) and the globulin content was insignificantly (p=0.281) decreased (11.373%) in BAR treated rats. There had been found a prominent increase in the total cholesterol (247.5%), and a decrease in HDL (35.835%) level within the rat serum. A very highly significant (p=0.001) increase (247.5%) of serum total cholesterol level had been observed, while a statistically highly significant decrease was observed in a case of HDL (35.835%) (p=0.008). After chronic administration of BAR to the rats, an increase of bilirubin level (14.015%) was noted in comparison to their control group (p=0.793). Finally, There was found an insignificant decrease in the plasma urea (10.922%) in the BAR treated rats (p=0.436), while BAR caused 9.862% increase in plasma uric acid. Conclusion: Therefore, Brhad Agnikumar Rasa will have been thought of safe for human therapeutic use at the counseled therapeutic doses.

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