Background: Fédération Internationale de Football Association (FIFA) World Cup 2022 in Qatar is a unique mega mass gathering event. Attendees from around the globe will meet in this small area for the first time in history. The chance for transmission of communicable diseases is high and requires a detailed elaboration of the diseases that may threaten the health of those attendees. Objective: To highlight the most common communicable diseases in Qatar that may threaten the health of Qatar 2022 attendees and provide advice and suggestions for preventive measures that should be taken. Evidence Review: We reviewed peer-reviewed articles to identify common health outcomes associated with previous FIFA World Cup tournaments. Then, we refined our review to focus on the most relevant infectious diseases that may threaten Qatar 2022. Relevant preventive measures and safety advice were also discussed. Results: Attendees of Qatar 2022 face unique risks for infectious diseases associated with this mega mass gathering event. Conclusion: Attendees should be aware of general preventive measures that should be taken and seek up-to-date information regarding their visit to Qatar 2022. Immunization status should be up to date. Authorities should promote health advice materials. Adequate stock of materials to attend to health-related needs should be obtained.