The aim of the study was to formulate bio adhesive vaginal tablets using natural tamarind gum. Acyclovir was chosen as a model drug. Tamarind gum was extracted from the seeds of tamarind fruit. Tablets were compressed by direct compression. Compatibility studies were done for the gum and drug. FTIR and DSC studies showed that there was no chemical interaction between the gum and the drug. All the prepared formulation showed satisfactory quality control parameters. Tablets showed good bio adhesion. It can be concluded that the prepared tablets can be effectively used as vaginal drug delivery system.