Introduction: This study was done with the objective of determining the frequency and distribution of teeth requiring endodontic treatment in Saudi Arabia subpopulation. Materials & Methods: A retrospective, cross-sectional study was done in the Department of Clinical Sciences, Dental Program, Batterjee Medical College, Jeddah, Saudi Arabia. Patient’s data (age, gender, arch and type of tooth involved) that underwent root canal treatment from 1st January 2018 to 31st December 2018 was collected and analyzed. Results: Out of 3731 patients, 538 teeth required endodontic treatment. More male patients undergone root canal treatment as compared to females, and most root canal treatments were done in young adult patients. Most of the teeth that required root canal treatment were posteriors. Conclusion: This study showed that root canal treatment was done more in males, in mandibular posteriors and in young adult patients.