amhsr-open access medicla research journals

Fried Tooth and Nail Syndrome with Possible Mutation - A Rare Entity


Ashwin Devasya*, Mythri Sarpangala, Ajeya Kumara and Rakshith S Shetty

Background: Tooth and Nail Syndrome (TNS) is a rare genetic disorder and one of the common types of Ectodermal Dysplasias (ED). Fried and Witkop Syndromes are two subtypes with similar clinical and radiological features with a difference in the inheritance pattern. just state the genetic difference. The condition is particularly of interest to dentists because of the challenges in prosthetic rehabilitation. Case report: This article reports a case of an 8-year- old girl whose parents came with a chief complaint of unerupted permanent teeth. Clinical examination showed the features of a possible syndrome with some missing teeth, thin scalp hairs and eyebrows, everted lips, dysplasia of nails and palmoplantar hyperkeratosis. Orthopantomograph showed missing mandibular primary central and lateral incisors and absence of permanent tooth buds. Based on the clinical findings and autosomal recessive inheritance pattern, the girl was diagnosed of Fried Tooth and Nail syndrome. Conclusion: The present case is a rare occurrence of Fried Tooth and Nail syndrome. Case also presents with palmoplantar hyperkeratosis, which is unusual, suggesting a possibility of mutation of gene responsible for the condition.

Select your language of interest to view the total content in your interested language

Awards Nomination
20+ Million Readerbase
Abstracted/Indexed in

  • Include Baidu Scholar
  • CNKI (China National Knowledge Infrastructure)
  • EBSCO Publishing's Electronic Databases
  • Exlibris – Primo Central
  • Google Scholar
  • Hinari
  • Infotrieve
  • National Science Library
  • ProQuest
  • TdNet
  • African Index Medicus
Annals of Medical and Health Sciences Research The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.
Submit your Manuscript