Gestational Diabetes Mellitus and its Correlation with Family History of Diabetes Mellitus: Systematic Review and Meta-analysis

Author(s): Ahmed Ali F Alazmi*, Yasamiyan Ali AlBurayh, Fahad Abdulrahman Almuzaini, Aseel Saud Alrefaei, Khalid Nasser Mubarki, Abdulaziz Ibrahim Alhonaizil, Maha Ali Almuhandis, Ahmed Abdulrahman Alolah, Abdulraouf Abdulaziz Alhojaily, Khaled Hatem Kariri, Ahmed Bahjat Alghamdi, Ali Fahad Alshehri, Heba Kamal Alfaris, Habab Mansour Alkhonizi and Reem Salem Mahfoudh

Background: Gestational Diabetes Mellitus (GDM), a common obstetric complication, is defined as any degree of glucose intolerance with onset or first popularity at some point of being pregnant, because traditional hazard factors, which include maternal age, weight problems, and ethnicity, do now not explain the superiority of GDM within the pregnant population, there’s good-sized interest in spotting nontraditional, novel chance factors e.g. family history of DM. Aim: This work aims to determine Gestational Diabetes Mellitus (GDM) and its correlation with the family history of Diabetes Mellitus (DM) patients. Literature Review: A systematic search was performed over different medical databases to identify family medicine studies, which studied the outcome of the GDM group versus the Non-GDM group of pregnant patients. Using the meta-analysis process, either with fixed or random-effects models, we conducted a meta-analysis on the family history of DM as a primary outcome, and on the previous maternal history of GDM as a secondary outcome. Nine studies were identified involving 7432 patients, with 997 patients in the GDM group, and 6435 patients in the Non-GDM group. The meta-analysis process revealed that the random-effects model of the meta-analysis process revealed a highly significant increase in the family history of DM and previous maternal history of GDM in the GDM group compared to the Non-GDM group (p<0.01 respectively). Conclusion: To conclude, Gestational Diabetes Mellitus (GDM), a common obstetric complication, is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Because traditional risk factors, such as maternal age, obesity, and ethnicity do not completely explain the prevalence of GDM in the pregnant population, there is considerable interest in recognizing nontraditional, novel risk factors. Family history of DM has an important role in gestational diabetes.


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