Background and Purpose: Grip strength is a good predictor of hand functions; it is an important part of hand assessment for proper hand function and integrity of muscles. It is not clear whether a relationship exists between hand grip strength and anthropometric measures of the upper limb from childhood period to adolescence period. The aim of this study was to evaluate the correlation between hand grip strength and some upper limb anthropometric measures and to detect the difference between boys and girls for all measured parameters in different school grades. Design: Cross Sectional study. Participants: Seven hundred and fifty seven healthy children of both sexes with age range between 7 to 18 years. Methods: Hand grip strength was assessed by hydraulic hand held dynamometer and it was correlated to some anthropometric measures including (Height, whole arm length, upper arm length, forearm length, Hand width (cm), weight (kg), percentile body mass index (PBMI), and hand grip strength for both dominant and non-dominant hands for each child in each grade separately. Results: A strong positive relationship between hand grip strength and anthropometric measures in primary grades was detected with a weak positive relationship in preparatory and secondary grades. Multiple regression analysis revealed that age, sex, weight and height were predictors of grip strength in both hands. Conclusion: It was concluded that hand grip strength had a significant relationship with some anthropometric measures of upper limb in Egyptian school children in different grades.