Aim of study: In certain clinical situations HDRILBT may be an effective alternative modality as a boost to external beam radiation therapy in advanced inoperable carcinoma esophagus. In this study, we evaluated the feasibility, complications and short term response of HDRILBT used as a boost after completion of 40 Gy EBRT with curative intent in inoperable advance stage esophageal cancer. Materials and Methods: After 40 Gy EBRT, 28 patients who could be intubated with 16 F Levine’s tube was given high dose rate (HDRILBT) and formed the study group. The prescription point was at 1 cm from the central axis of the oesophageal catheter. A total dose of 10 Gy in 2 fractions at weekly intervals was prescribed. Results: Treatment result was analysed after 3 months of completion of treatment. It was consisted of clinical evaluation, endoscopic evaluation and contrast enhanced CT scan thorax of the patients. Grade 1 & 2 oesophagitis was seen in 21 patients. 3 patients had Grade 3 & 4 oesophagitis (RTOG scale). Stricture formation was seen in 3 patients. In one patient, tracheoesophageal fistula was developed 3 months after treatment. Complete Response was seen in 20 patients (71%). Partial response was seen in 4 patients (14%). Stationary and progressive disease was seen in 4 patients (14%). Relief in dysphagia was seen in 22 (78%) patients. Conclusion: In selected cases use of HDRILBT as a boost to EBRT is a feasible option to obtain a higher dose for improved local control with acceptable complications.
Select your language of interest to view the total content in your interested language
Annals of Medical and Health Sciences Research received 15898 citations as per google scholar report