Background: Asthma is a chronic inflammatory airways disease, which produces an increase in the reactivity and recurrent episodes of wheezing, respiratory distress and cough. Pulmonary rehabilitation (PR) and education is a strategy that improves the quality of life and health status of patients. Objective: To determine the impact of PR with an educational component on functional aerobic capacity, symptoms, anxiety, depression and quality of life related to health in patients with severe asthma. Methods: Prospective and non-controlled intervention study in 11 patients, who underwent the 6-minute walking test, spirometry, the Medical Research Council dyspnoea scale (MRC), the Hospital Anxiety and Depression Scale questionnaire (HADS) and the St George’s Respiratory Questionnaire (SGRQ). The PR program comprised 8 weeks of muscle strength training, aerobic capacity and educational component with individual and group sessions. Results: 11 patients completed the PR program. The average age was 55.82 ± 19.96. The FVC had an average of 49.21 of the predicted SD ± 14.94. The distance covered in the 6-minute walking test had a difference in means and DE of 53.36 ± 50.7, being clinically significant. In anxiety and depression there was a mean difference of 1.18 ± 2.31 and 1.54 ± 2.62 respectively, anxiety with a p-value of 0.079 and depression with a p-value of 0.12. They did not have a statistically significant improvement, and in the quality of life related to health, the domain that presented the greatest improvement were activities, with a p-value of 0.000. Conclusions: In a PR program, education showed good results regarding variables such as functional aerobic capacity, symptoms and quality of life in patients with severe asthma.