The aim of the study was to evaluate the effect of local blood substitute rheomannisol on some metabolic, functional and structural parameters of the organism in the dynamics of development of experimental hemolytic anemia caused by phenyl hydrazine. Objects & Methods of Research: The object of research was white rats (n=120) in vivarian conditions of the tashkent medical academy. The study used experimental, biochemical and statistical methods. The practical results of the study are as follows: Data have been obtained that allow a deeper understanding of the formation of pathogenetic developmental mechanisms of hemolytic anemia. It is based on the use of a new blood-replacing drug Reomannisol to correct the degenerative mechanisms in hemolytic anemia, which has reduced the material costs and improved the quality of life in the treatment of patients and has been proven in practice.