AMHSR

Low HDL is not associated with Coronary Heart Disease in Non-diabetic Agrarian Rural Community in Central India

Author(s): Sheetal Ingle, Sumedh U Jajoo*, Ulhas N Jajoo, Sheetal Bodkhe, Subodh S Gupta, Bharti A Taksande and Anjali Bhatt

Background & objectives: Coronary Heart Disease (CHD) is the disease of urbanisation. However, the recent evidence suggests that CHD is becoming more prevalent in low socioeconomic group, including rural areas. The role of lipids and lipoproteins in pathogenesis of CHD factors is well established. Methods: We performed a case-control study to determine association of dyslipidaemia with CHD in individuals above 60 years residing in the rural community of central India. Successive consenting nondiabetic subjects who are diagnosed to have definite CHD (electrocardiographically defined; exercise test and echocardiographically/angiographically confirmed) but are not on statins were enrolled (cases n=41). Subjects with matched age group, gender and socioeconomic status, with no evidence of CHD, nondiabetic and not on statin, were recruited as controls (n=164). Results: Isolated low HDL level was the most common finding (80% in male, 90% in female cases and 74% in male and 95% in female controls). No statistically significant difference was found in cases and controls in total cholesterol (p=0.3342), HDLCholesterol (p=0.4864), TG (p=0.997), LDL cholesterol (p=0.1945) and VLDL cholesterol (p=0.5943) and lipid ratios i.e. total cholesterol: HDL (p=0.075), TG: HDL (0.65) and LDL: HDL (0.05). The correlation coefficient between serum HDL and waist circumference, serum HDL and BMI indicated no association. There was no difference in the distribution of S. HDL-C among subjects who belonged to different socioeconomic strata. Conclusion: Overall prevalence of lipid abnormalities is low in our population except isolated low HDL level. We found that isolated low HDL level was not associated with CHD in our rural community.


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