Cancer is a disease that explains the vulnerability health with an impact on occupational health and public health, even when in Mexico the prevalence rate is lower than the other member Countries OECD, Modelling variables reported in the cancer literature regarding its weighting in a public hospital. A non-experimental, cross-sectional and exploratory study with a nonrandom selection of 104 Patients from a public hospital in the State of Mexico was held. Scale Variables psychosocial determinants of treatment adherence built. From a structural model showed relationships in adjustment paths determining treatment adherence behavior. The boundaries of design, sampling and analysis of the study are noted and recommended to include organizational and psychological variables supported in theories of Organizations and theories of personality.