Non-invasive Follicular Tumour with Papillary-Like Nuclear Features (NIFTP) ??? Is It Like a Tiger in a Cage?

Author(s): Sheetal Arora*

Context: This is an article which presents a review of non-invasive follicular tumour with papillary like nuclear features (NIFTP). It includes its current definition and histopathological characteristics. The article differentiates NIFTP from follicular variant of papillary carcinoma thyroid. Objectives: This article emphasises on the diagnostic features of NIFTP. It discusses its histopathological features, molecular profile and the importance of grossing the capsule to exclude the diagnosis of carcinoma. The article focuses on the problems which are usually associated with the diagnosis and management of NIFTP. Data sources: Review of articles on NIFTP and articles focusing on differences between NIFTP and papillary carcinoma thyroid. Conclusion: NIFTP is a low risk indolent neoplasm which when diagnosed using appropriate histopathological criteria are not associated with metastatic or recurrent diseases at least for intermediate period of follow up. The article differentiates between true neoplastic papillae and hyperplastic or degenerative papillae and how does it affects the diagnosis of NIFTP. It also discusses cytological features, micro NIFTP and features of the neoplasm which are still to be studied, which may affect the outcome of the disease.


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