Oral leukoplakia is one of the most common potentially malignant disorders seen in our Indian Subcontinent. It is present in relation to the consumption of tobacco products, mainly smoking. The most common site for the occurrence of leukoplakia is the buccal mucosa. There is a hypothesis that red component of leukoplakia may be attributed to the fungal hyphae. The aim of this study was to analyze the management of leukoplakia using antifungal drug. The study picked out 99 leukoplakia patients from the 89000 cases of leukoplakia case sheets available. The study sample consisted of 94 male and 5 females with leukoplakia. The majority of the patients were in the age of 40-50 years with a mean of 48.66 years. The study sample had 77 homogenous variants and 22 non-homogenous variants. The vast majority of patients were males with the homogenous variant. However gender based analysis showed no association (P>0.05). An association analysis shows that there is no statistically significant association between the usage of antifungals in leukoplakia and the clinical variant (P>0.05). As a conclusion, within the limitations of the study, antifungal were used to a limited extent in the management of leukoplakia which implies that there was a limited chance of super added fungal infection.
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