Background: Type 2 diabetes comes with various complications and this may be compounded by morbidities of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Aims: This study examined the prevalence of HBV and HCV infectionst among type 2 diabetics as well as its associated factors. This randomized cross‑sectional study was conducted at the Diabetic Clinic of the Central Regional Hospital, Cape Coast between December 2012 and April 2013. Subjects and Methods: A well‑structured questionnaire was used to recruit 110 type 2 diabetics. Venous blood samples were collected for the estimation of blood glucose and to screen for HBV and HCV infections. Data analysis was carried out using SPSS Version 17.0. Descriptive analysis was performed and results expressed as means (SD) and n (%). P < 0.05 was considered significant. Results: Prevalence of HBV in type 2 diabetics was 5.5% (6/110). No type 2 diabetic was positive for HCV. The prevalence of HBV infection in the type 2 diabetes mellitus (T2DM) participants was higher (5.5% [6/110]) than that of HCV (0/110). A total of 69.1% (76/110) T2DM patients had poor glycemic control. Mean waist and hip circumference was higher among HBV‑negative T2DM participants (99.3; 106.9) than HBV‑positive participants (87.2; 101.8). Conclusions: The seroprevalence of HBV was higher than that of HCV in T2DM patients. T2DM patients would require necessary preventive measures like prophylaxis, to reduce the risk of HBV infection and its ramifications.