Necrotizing Autoimmune Myopathy (NAM) is a sub-type of inflammatory myopathy which is characterized by acute or subacute onset progressive weakness of the proximal muscle of the body. Recognition of this subtype is important as prognosis varies with subtype. As for other myopathies, elevated CPK-total is hallmark. On the basis of histopathology differentiation is made from others subtypes of inflammatory myopathy. Most common antibodies associated with Necrotizing Autoimmune Myopathy (NAM) are Anti-Signal Recognition Particles (antiSRP) and anti-3 Hydroxy- 3-Methylglutaryl-Coenzyme A Reductase (anti-HMGCR) antibodies. Patients with anti-SRP antibodies often present clinically with rapidly progressive proximal muscle weakness leading to significant disability. We are here presenting a clinical case of a patient with autoimmune necrotizing myopathy with positive anti-SRP autoantibodies and typical clinical presentation, who responded to treatment on diagnosis.
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