Stevens Johnson Syndrome (SJS) is a rare immune-mediated hypersensitivity disorder that present with mucocutaneous blistering reactions with epidermal detachment and extensive necrosis. Stevens-Johnson syndrome is mainly a reaction to medication, such as sulfonamide, aminopenicillin, quinolone, and cephalosporin. The aminoquinolines, chloroquine and hydroxychloroquine, are widely used in the treatment of many diseases such as malaria and rheumatoid arthritis. Recently it was suggested as a treatment for COVID-19. We report a series of 11 patients, who developed SJS after intake of hydroxychloroquine. More attention should be given for hydroxychloroquine especially with its increased use during COVID-19 pandemic.