Study of Carotid Intimal Medial Thickness in Chronic Kidney Disease at Rural Teaching Hospital

Author(s): Sashiraj Lahoti, Sunil Kumar* and Sachin Agrawal

Background: Patients with Chronic Kidney Disease (CKD) are associated with increased morbidity, mortality, and increased healthcare expenditures as they are at high risk for developing cardiovascular disease (CVD). Carotid intimal medial thickness (CIMT) has been found to correlate with atherosclerosis major risk factors of CVD. Method: This was a prospective case control study of carotid intimal medial thickness in patients of CKD. A total of 150 patients of CKD and equal number of age and sex matched controls were enrolled. Bilateral assessment of intimal medial thickness was done in common carotid artery. Statistical analysis was done by using descriptive and inferential statistics using the Chi square test, z-test for difference between two means, Pearson’s Correlation coefficient and Multiple Regression Analysis and software used in the analysis were the SPSS 22.0 version. Results: Out of total 300 cases, 114 (76%) patients of CKD and 113 (75.33%) control were male. CIMT in CKD patients was between 0.80 ± 0.28 mm and 0.64 ± 0.16 in control p=0.0001. CKD patients with diabetes were having mean CIMT 1.09 ± 0.22 mm in comparison to controls with diabetes having mean CIMT 0.63 ± 0.16 mm, p=0.0001. CKD patients with hypertension were having mean CIMT 0.76 ± 0.27 mm in comparison to controls having mean CIMT 0.62 ± 0.18 mm, p=0.0001. Conclusion: Mean CIMT was increased in all stages of CKD and there was no significant difference in CIMT in different stages of CKD. Patients having hypertension was having higher mean CIMT in comparison to patients having normal blood pressure, patient with diabetes had high mean CIMT as compared to mean CIMT of controls having diabetes.

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