Attention deficit hyperactivity disorder (ADHD) is today one of the most relevant disorders in the clinical setting, not only because of its prevalence but also because of its high comorbidity with other diseases. Its peculiar characteristics undoubtedly represent a risk factor, which explains the connection with the use of addictive substances. This report aims to show the link between ADHD and substance use since both pathologies show significant interactions. This was possible to observe thanks to the neuropsychological deficits of the subjects with ADHD, such as impulsivity, lack of inhibitory control and emotional regulation difficulties, which interfere in aspects as significant as social behavior. Both evaluation and treatment represent a considerable challenge that requires exhaustive information as part of a differential diagnosis. The combination of adequate therapeutic strategies linked to correct pharmacological treatment represents an essential target in today's clinic.