Background: Since there is no diseaseâ�?�?specific instrument for measuring qualityâ�?�?ofâ�?�?life (QOL) in Ostomy patients in Persian language. Aim: This study was designed to translate and evaluate the validity and reliability of City of Hopeâ�?�?quality of lifeâ�?�?Ostomy questionnaire (COHâ�?�?QOLâ�?�?Ostomy questionnaire). Subjects and Methods: This study was designed as crossâ�?�?sectional study. Reliability of the subscales and the summary scores were demonstrated by intraâ�?�?class correlation coefficients. Pearson’s correlations of an item with its own scale and other scales were calculated to evaluated convergent and discriminant validity. Clinical validity was also evaluated by knownâ�?�?group comparisons. Results: Cronbach’s alpha coefficient for all subscales was about 0.70 or higher. Results of interscale correlation were satisfactory and each subscale only measured a single and specified trait. All subscales met the standards of convergent and discriminant validity. Known group comparison analysis showed significant differences in social and spiritual wellâ�?�?being. Conclusion: The findings confirmed the reliability and validity of Persian version of COHâ�?�?QOLâ�?�?Ostomy questionnaire. The instrument was also well received by the Iranian patients. It can be considered as a valuable instrument to assess the different aspects of health related qualityâ�?�?ofâ�?�?life in Ostomy patients and used in clinical research in the future.
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