Sports activities play an important role in immune system function. Multiple short- longterms, intense, endurance and regular exercise have different effects on immune system. In this study the effect of eight weeks aerobic training on serum levels of pro-inflammatory cytokines (IL-17) and immunoglobulins (IgA˛ IgM˛ IgG and IgE) in patients with type 2 diabetes were examined. Methods of study: 60 male type II diabetic patients age ranges from 30 to 50 years old with fasting blood glucose between 150-250 mg/dl were selected by cross-sectional clinical trial study. An eight-week program of aerobic exercise three hours per week, each week one hour training session was performed for them. Then 5 ml blood sample before starting the first session and 24 hours after eight weeks of training was taken. Serum levels of immunoglobulins E, G, M, A and IL-17 in patients before and after exercise were measured by ELISA method and the results were analyzed using statistical tests. Results: The results showed that serum immunoglobulin levels of patients after 8 weeks of aerobic exercise significantly altered but the serum levels of IL- 17 was not significantly changed. Conclusion: Significant changes in the levels of serum immunoglobulin levels of athlete’s diabetic patients hoping that exercise can improve their immune systems function. No significant changes in IL-17 after 8 weeks of training were due to the low-intensity exercise that requires further investigation.