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The Effect of 8 Weeks Aerobic Training on Serum Levels of Pro-inflammatory Cytokines (IL-17) and Immunoglobulins (IgA, IgM, IgG and IgE) Levels in Patients with Type 2 Diabetes

Author(s): Hossein AliKhazaei, Arman Jalili*, Seyed Reza Mousavi Gilani, Ali Alidadi, MohammadSafdari, Nezarali Moulaei, JavidDehghan Haghighi, Nourollah Ramroudi, Alireza Khosravi, Gholamreza Solemani, Vahid Sheikie, HedatatollahNahvi, Hossein Bagheri, Bahman Khazaei, Ehsan Khazaei, Amin Khazaei, Milad Dehbashi, MortezaSalarzaei and Nima Rezaei

Sports activities play an important role in immune system function. Multiple short- longterms, intense, endurance and regular exercise have different effects on immune system. In this study the effect of eight weeks aerobic training on serum levels of pro-inflammatory cytokines (IL-17) and immunoglobulins (IgA˛ IgM˛ IgG and IgE) in patients with type 2 diabetes were examined. Methods of study: 60 male type II diabetic patients age ranges from 30 to 50 years old with fasting blood glucose between 150-250 mg/dl were selected by cross-sectional clinical trial study. An eight-week program of aerobic exercise three hours per week, each week one hour training session was performed for them. Then 5 ml blood sample before starting the first session and 24 hours after eight weeks of training was taken. Serum levels of immunoglobulins E, G, M, A and IL-17 in patients before and after exercise were measured by ELISA method and the results were analyzed using statistical tests. Results: The results showed that serum immunoglobulin levels of patients after 8 weeks of aerobic exercise significantly altered but the serum levels of IL- 17 was not significantly changed. Conclusion: Significant changes in the levels of serum immunoglobulin levels of athlete’s diabetic patients hoping that exercise can improve their immune systems function. No significant changes in IL-17 after 8 weeks of training were due to the low-intensity exercise that requires further investigation.


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