Background: The Chronic Neck Pain is the process of degeneration of the cervical spine and the vertebral bodies. It affects the vertebral bodies and intervertebral disks of the neck and finally leads to herniation of the disks as well as osteophytes and ligament hypertrophy. Purpose: The cross-sectional analytical study focused on the effect of people Lifestyle during COVID-19 quarantine on number of cases of Musculoskeletal Disorders (MSD) especially Non-Specific Chronic Neck Pain in Jeddah (Saudi Arabia), and compare number of cases before and after the quarantine with taking into account the difference in age and gender. COVID-19 period was characterized by lockdown and quarantine. Methods: data collected from one hospital in Jeddah according the patients diagnosed by Non-Specific Chronic Neck Pain in between (1 August 2019 to 30 September 2020) male and female, age 28- 40, exclusion criteria: patient with history of fracture in cervical spine, cervical tumors, neck trauma, patient with age more than 40 and less than 28. Collecting the data of 7 months before the quarantine and 7 months during the quarantine. Results: After collecting and counting data, we noticed that there was a doubling in the number of cases and neck problems, and an increase in the number of cases during quarantine by (58.6%), while in females by (46.25%) in general. It increased by 53.3% of cases. Conclusion: The results clearly showed that the effect of people’s lifestyle during the quarantine of the emerging corona virus, COVID-19, on the number of cases of Musculoskeletal Disorders (MSD), especially chronic non-specific neck pain in Jeddah (Saudi Arabia), and its impact on males more than females.