Background: The prevalence of obesity increases in both developed and developing countries. Beside individuals have started to seek ways of changing their aesthetic appearance by easy methods. Objectives: This study was conducted in an attempt to identify the effect of methods performed through a device for regional weight loss on the regional fat mass and body composition to reduce regional fat and cellulites. Materials and Methods: A total of 68 women willing to reduce fat on their gluteal-femoral regions participated in the study. Three different methods were adopted for the participants divided into three groups for regional weight loss in line with the medical advice of the center they consulted. The methods used are Ultrasound & Radiofrequency (Exilis-2011, BTL Medical Devices), cavitation method (Ultrasound Cavitation Eximia -2010, 1065 DJ Cosmo Plus), and Shock Wave Treatment (AWT Acoustic Wave Therapy D- Actor, 2007-2008 Medlaser Storz). Arithmetic average and standard deviation were used for statistical assessment of data, and an analysis of variance test on repeated measures was conducted. Results: The type of the method led to a significant difference (p<0.05) between the first and the final measurements in terms of body weight, waist and hip circumference, BMI, total fat mass, right leg/left leg and trunk fat mass. Conclusion: It was found out that the methods adopted proved to be factors contributing to a significant decrease in total body fat, regional fat mass and cellulite of all participants.