Background: Prostate cancer is a significant healthcare burden in bothdeveloping and under developed countries. Efforts in Saudi Arabia may behindered by the unclarity of awareness of predictors of early prostate cancerscreening, given the complexity of such screening. Objective: The objectiveof this study was to assess awareness levels of early screening of prostatecancer and its predictors among Saudi men.Methods: A cross-sectional participatory approach was used to assess theawareness levels of early screening of prostate cancer among Saudi menwithin the age group for which early prostate cancer screening isrecommended.Results: Participants were recruited out of those admitted to outpatientclinics of the five largest tertiary-care hospitals. Four-hundred and eighteenSaudi outpatient men aged 40–65 years were interviewed. Of all participants,79.2% had heard of prostate cancer. When comparing eligible age groups,there was a significantdifference in the percentage of men who had notundergone prostate screening (p-values <.0001). Across all eligible agegroups, 65.8% of participants had not been advised to undergo prostatescreening by their primary care physicians. In each age group, more than75% of men reported that they would consider early screening for prostatecancer.