Background: Mental annoyance caused by noise pollution is a common phenomenon in modern societies, especially in industry. Noise annoyance is dependent on Psychological and physiological characteristics of the individual. Aim: This study aimed to determine the role of personality characteristics and demographic factors on the noise annoyance caused by noise pollution in the industrial workers of the industrial city of Qom. Subjects and methods: In this descriptive correlational study 158 workers in various industries of Qom industrial city on classification quota methods were selected and evaluated in this study. All workers with mental and physical disorders, uninsured workers and Seasonal and children workers were excluded from the study. A general questionnaire was used for collecting demographic and contextual information including age, work experience and education. Also, the Weinstein noise annoyance scale was used to obtain information on annoyance. The NEO-FFI personality questionnaire (short form 60) was used to measure the personality traits of the research community. Finally, the collected data were analyzed using SPSS software. Results: In general, in 39% people noise annoyance score is between 50% and 75%, and in 33% people was between 75% and 100%. The results showed that, the average of noise annoyance in male and female workers is respectively 61 and 73/99. Also the results showed that there was a significant relationship between neuroticism and Noise annoyance and there is no significant correlation between other personality characteristics of individuals with the Noise annoyance. According to the results of this study, there is no significant relationship between noise annoyance with any individual characteristics (age, sex, marital status and education). Conclusion: According to the results of this study, neuropsychiatric personality has an effective role in increasing the noise annoyance and Negative people are more likely to suffer from noise annoyance than others. Due to the fact that more people in the industry are suffering from noise annoyance, further research is recommended to manage people’s noise annoyance based on their personality traits.