Background: Patients with angina pectoris have poor quality of life. This study was done to detect the social support effect on quality of life in patients with angina pectoris symptoms. Materials and Methods: In this comparative descriptive analytical study, 106 patients with angina pectoris were studied; 48 patients with low level and 58 patients with high level social support. Gathering data was done by the Iranian version of Seattle angina questionnaire, social support questionnaire and social readjustment rating scale. Results: Findings showed the mean score of Seattle angina questionnaire was 50.32 ± 17.65 and for social support was 50.32 ± 18.3. The majority of samples had desired score for perceived stress over the past year. Multiple liner regression showed any one of items could not predict quality of life in high level social support patients, but this model showed in patients with low and high social support only perceived stress is predictor of quality of life. Conclusion: It is obvious stress can effect on all aspect of life and decrease quality of life in each person especially in patients with coronary artery disease.