The use of ozone became a normal practice after the initial studies by Dr. H. H. Wolff (1979) in Germany. Today, in this Nation, is used by over 12.000 physicians but only after Bocci’s study it is used very proficiently either in chronic inflammatory diseases or in orthopedics. It has been shown to be very effective and absolutely atoxic when used in dosages which induce only a well-tolerated oxidative stress either for autohaemotherapy or in orthopedics. It will be described what ozone is, how it can be proficiently used, what are its messengers, what will be their effects and what are the therapeutic effect.
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