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Transplacental Transfer of Macromolecules: Proving the Efficiency of Placental Transfer of Maternal Measles Antibodies in Mother: Infant Pairs

Author(s):

Baba UA, Ashir GM, Mava Y, Elechi HA, Saidu G, Kaleb AA

Background: Smaller substances <600 Daltons (Da) can transit human placenta while larger ones >1000 Da may not. This may not be consistent because maternal measles antibodies (MMA) are large immunoglobulin G molecules with molecular weight of 150,000 Da, could cross the placenta in motherâ??infant pairs. Aim: The objective was to assess the efficiency of placental transfer of MMA in motherâ??infant pairs at birth. Subjects and Methods: Sera collected from motherâ??infant pairs were analyzed for MMA using enzymeâ??linked immunosorbent assay. Gestational age (GA) of newborns was determined using the last menstrual period, ultrasound scan, and the Dubowitz criteria, whereas their birth weight (BW) was measured using the bassinet weighing scale. Results: Correlation coefficient (r) of MMA of motherâ??infant pairs at birth was significant (P < 0.01) and comparison of mean MMA for term and postterm deliveries were significant (P = 0.001) and (P = 0.007) respectively. Goodman and Kruskal’s Gamma rank correlation of GA and BW was also significant ( P< 0.001). Conclusion: Passage of MMA across placenta was efficient and newborn infants are protected from measles at birth.


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Annals of Medical and Health Sciences Research The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.
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