Dilfuza S Matkarimova

Department of Hematology, Transfusiology and Lab Affairs, Tashkent Medical Academy, Tashkent, Uzbekistan

Publications

  • Research Article   
    Genetic Investigation of Chronic Viral Hepatitis C
    Author(s): Sevara B Azimova* and Dilfuza S Matkarimova

    Aim: The aim of the study was a comparative analysis of genotypic variants of TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. Materials & Methods: The material for the molecular genetic study was the peripheral blood of the examined persons. DNA isolation was carried out according to the standard procedure with some modifications and using the reagents of the “Interlab service” company (Russia). Identification of alleles of gene polymorphism was carried out using polymerase chain reaction. Results: The analysis of the effect of TNF-α gene genotypes on the course of the disease indicates an increased risk of CVHC development with both moderate and highly active course of the disease in carriers of the G/A+A/A genotype combination. Conclusion: The data obtained allow us to conclude.. Read More»
    10.54608.annalsmedical.2022.29

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