El-Bassyouni HT

Dr, Department of Clinical Genetics, National Research Centre, El-Tahreer street, Dokki, Cairo, Egypt

Publications

• Original Article   
  Oxidative Stress ???a Phenotypic Hallmark of Fanconi Anemia and Down Syndrome: The Effect of Antioxidants
  Author(s): El-Bassyouni HT*, Afifi HH, Eid MM, Kamal RM, El-Gebali HH, El-Saeed GSM, Thomas MM and Abdel-Maksoud SA
  
  Background: Oxidative stress plays a major role in the pathogenesis of leukemia‑prone diseases such as Fanconi anemia (FA) and Down syndrome (DS). Aim: To explore the oxidative stress state in children with DS and FA by estimating the levels of antioxidants (e.g., malondialdehyde [MDA], total antioxidant capacity, and superoxide dismutase [SOD] activity) and DNA damage, and to evaluate of the effect of antioxidant treatment on these patients. Subjects and Methods: The study included 32 children clinically diagnosed with (15 patients) and FA (17 patients) in addition to 17 controls matched for age and sex. MDA, total antioxidant capacity, SOD activity, and DNA damage were measured. Antioxidants including Vitamin A, E, and C were given to the patients according to the recommended daily allowance for 6 months. Clinical follow‑up and re‑evaluation were conduc.. Read More»