Immadi Laxmi

Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

Publications

  • Research Article   
    Comparison of Inflammatory Markers in Saliva before and after Endodontic Treatment
    Author(s): Immadi Laxmi, Sujith Kumar and Sindhu Ramesh*

    In endodontic infections, inflammatory mediators such as cytokines are released, recruited and retained until the infection is eradicated. Root canal therapy is performed to prevent the spread of infection. The aim of this study was to investigate the effects of root canal debridement (cleaning and shaping) on periapical inflammation by measuring the levels of inflammatory cytokines, Interleukin-8 (IL-8) and Interleukin-10 (IL-10). The study includes twenty patients with pulp necrosis and asymptomatic apical periodontitis. Periradicular samples were collected using paper points before and after root canal debridement. Cytokine levels were determined by Sandwich Enzyme-Linked Immunosorbent Assay (ELISA). Data were analyzed using paired t-test (PASW Statistics 18) (P=0.05). All samples showed the presence of IL-8 and IL-10 prior to root canal debridement. Significantly reduced levels (p.. Read More»

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